We thank the DTI MMI project and its industrial/academic partners (Prof. R. Catlow, Royal Institution; Dr. A. Danopoulos, University of Southampton; Dr. F. Hancock and Dr. A. Zanotti-Gerosa, Johnson Matthey; Dr. P. Levett and Dr. A. Pettman, Pfizer; Dr. P. Hogan and Dr. M. Purdie, AstraZeneca; Dr. P. Ravenscroft, GlaxoSmithKline) for financial support and valuable suggestions. We also thank Dr. N. Winterton for helpful suggestions.
Insight into and Practical Application of pH-Controlled Asymmetric Transfer Hydrogenation of Aromatic Ketones in Water†
Article first published online: 25 APR 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 22, pages 3407–3411, May 30, 2005
How to Cite
Wu, X., Li, X., King, F. and Xiao, J. (2005), Insight into and Practical Application of pH-Controlled Asymmetric Transfer Hydrogenation of Aromatic Ketones in Water. Angew. Chem. Int. Ed., 44: 3407–3411. doi: 10.1002/anie.200500023
- Issue published online: 24 MAY 2005
- Article first published online: 25 APR 2005
- Manuscript Received: 4 JAN 2005
- asymmetric catalysis;
- transfer hydrogenation
Much faster, more enantioselective, and more-productive catalysis was attained in the asymmetric transfer hydrogenation of aromatic ketones with the Noyori–Ikariya Ru–Ts-dpen catalyst in water under slightly basic conditions (see scheme). At low pH values, the reaction was much less efficient and appears to operate through a different mechanism.