This work was made possible by a grant from The Danish National Research Foundation. We are grateful to Dr. Jacob Overgaard for X-ray crystallographic analysis.
Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of α-Substituted α-Cyanoacetates†
Article first published online: 13 APR 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 19, pages 2896–2899, May 6, 2005
How to Cite
Poulsen, T. B., Alemparte, C., Saaby, S., Bella, M. and Jørgensen, K. A. (2005), Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of α-Substituted α-Cyanoacetates. Angew. Chem. Int. Ed., 44: 2896–2899. doi: 10.1002/anie.200500144
- Issue published online: 3 MAY 2005
- Article first published online: 13 APR 2005
- Manuscript Received: 14 JAN 2005
- asymmetric catalysis;
- Mannich bases;
Metal-free catalysis: Highly functionalized molecules with two contiguous stereocenters are easily accessed in high yield with high enantio- and diastereoselectivity by using a commercially available organocatalyst ((DHQD)2PYR, see scheme). The easily removed Boc protecting group in the product is an added value to this method as an important tool in asymmetric synthesis.