Review

Metathesis Reactions in Total Synthesis

  1. K. C. Nicolaou Prof. Dr.1,2,
  2. Paul G. Bulger Dr.1,2,
  3. David Sarlah1,2

Article first published online: 8 JUL 2005

DOI: 10.1002/anie.200500369

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 44, Issue 29, pages 4490–4527, July 18, 2005

Additional Information

How to Cite

Nicolaou, K. C., Bulger, P. G. and Sarlah, D. (2005), Metathesis Reactions in Total Synthesis. Angew. Chem. Int. Ed., 44: 4490–4527. doi: 10.1002/anie.200500369

Author Information

  1. 1

    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-2469

  2. 2

    Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

Publication History

  1. Issue published online: 8 JUL 2005
  2. Article first published online: 8 JUL 2005
  3. Manuscript Received: 31 JAN 2005

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1657K)

Keywords:

  • alkene metathesis;
  • alkyne metathesis;
  • enyne metathesis;
  • natural products;
  • total synthesis

Abstract

With the exception of palladium-catalyzed cross-couplings, no other group of reactions has had such a profound impact on the formation of carbon–carbon bonds and the art of total synthesis in the last quarter of a century than the metathesis reactions of olefins, enynes, and alkynes. Herein, we highlight a number of selected examples of total syntheses in which such processes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency. Judging from their short but impressive history, the influence of these reactions in chemical synthesis is destined to increase.

View Full Article (HTML) Get PDF (1657K)