Generous financial support by the MPG, the Fonds der Chemischen Industrie, and the Merck Research Council is gratefully acknowledged. We thank Dr. D. De Souza for helpful comments and discussions and Dipl.-Chem. J. T. Jensen for preliminary experiments on the synthesis of the acid segment.
Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne–Yne Metathesis†
Article first published online: 21 APR 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 22, pages 3462–3466, May 30, 2005
How to Cite
Fürstner, A. and Turet, L. (2005), Concise and Practical Synthesis of Latrunculin A by Ring-Closing Enyne–Yne Metathesis. Angew. Chem. Int. Ed., 44: 3462–3466. doi: 10.1002/anie.200500390
- Issue published online: 24 MAY 2005
- Article first published online: 21 APR 2005
- Manuscript Received: 1 FEB 2005
- natural products
Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed CC bond-formation reactions, including a ring-closing enyne–yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology.