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Keywords:

  • alkynes;
  • cross-coupling;
  • macrocycles;
  • metathesis;
  • natural products
Thumbnail image of graphical abstract

Selective actin-binding is the most prominent biochemical property of the scarce marine natural product latrunculin A (see formula). Modern metal-catalyzed C[BOND]C bond-formation reactions, including a ring-closing enyne–yne metathesis (shown in red), now open a convenient, flexible, and productive entry to this important probe molecule for chemical biology.