SEARCH

SEARCH BY CITATION

Keywords:

  • amino alcohols;
  • asymmetric catalysis;
  • chiral ligands;
  • Mannich reaction;
  • zinc
Thumbnail image of graphical abstract

An achiral unit is shown to be better than a chiral unit in promoting an asymmetric reaction. Non-C2-symmetric linked-binols 1 with one chiral 1,1′-bi-2-naphthol unit and one flexible achiral unit are employed as ligands in direct catalytic asymmetric Mannich-type reactions (see scheme; TON=turnover number). With as little as 0.01 mol % of ligand 1 a and 0.04 mol % of Et2Zn, the reaction proceeded smoothly to give the product in 98 % ee.