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Recent Progress in Asymmetric Allylic Substitutions Catalyzed by Chiral Copper Complexes



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Copper complements palladium as a catalyst of asymmetric allylic substitutions (see scheme). Palladium catalysis requires soft nucleophiles to ensure high stereo- and regioselectivity, whereas hard nucleophiles such as Grignard and organozinc reagents may be used under copper catalysis. Vast progress during the last decade reveals the promising future of copper catalysis in this asymmetric transformation.