We warmly thank the NSF (CHE 0213522) for financial support and Takasago (Dr. Takao Saito and Mr. Hideo Shimizu) and Prof. Sannicolo (University of Milan) for supplying the segphos and bitianp ligands, respectively, used in this study.
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Communication
CuH in a Bottle: A Convenient Reagent for Asymmetric Hydrosilylations†
Article first published online: 26 AUG 2005
DOI: 10.1002/anie.200500800
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Lipshutz, B. H. and Frieman, B. A. (2005), CuH in a Bottle: A Convenient Reagent for Asymmetric Hydrosilylations. Angew. Chem. Int. Ed., 44: 6345–6348. doi: 10.1002/anie.200500800
- †
Publication History
- Issue published online: 30 SEP 2005
- Article first published online: 26 AUG 2005
- Manuscript Revised: 23 JUN 2005
- Manuscript Received: 4 MAR 2005
Keywords:
- asymmetric synthesis;
- copper;
- hydrides;
- hydrosilylation;
- P ligands
Bottled for freshness: [{(R)-DTBM-segphos}CuH] (see formula; DTBM=3,5-di-tert-butyl-4-methoxy) generated in situ represents the first reported copper hydride reagent that can be stored and used over time without loss of activity in several types of asymmetric hydrosilylation reactions.