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CuH in a Bottle: A Convenient Reagent for Asymmetric Hydrosilylations


  • We warmly thank the NSF (CHE 0213522) for financial support and Takasago (Dr. Takao Saito and Mr. Hideo Shimizu) and Prof. Sannicolo (University of Milan) for supplying the segphos and bitianp ligands, respectively, used in this study.


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Bottled for freshness: [{(R)-DTBM-segphos}CuH] (see formula; DTBM=3,5-di-tert-butyl-4-methoxy) generated in situ represents the first reported copper hydride reagent that can be stored and used over time without loss of activity in several types of asymmetric hydrosilylation reactions.