In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Authors

  • Evgueni E. Nesterov Dr.,

    1. Department of Chemistry and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Fax: (+1) 617-324-0505
    2. Current address: Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
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  • Jesse Skoch,

    1. Department of Neurology/Alzheimer's Disease, Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
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  • Bradley T. Hyman Prof. Dr.,

    1. Department of Neurology/Alzheimer's Disease, Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
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  • William E. Klunk Prof. Dr.,

    1. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
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  • Brian J. Bacskai Dr.,

    1. Department of Neurology/Alzheimer's Disease, Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
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  • Timothy M. Swager Prof. Dr.

    1. Department of Chemistry and Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Fax: (+1) 617-324-0505
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  • This research was supported by NASA and the U.S. Army through the Institute for Soldier Nanotechnologies, under contract DAAD-19-02-D-0002 with the U.S. Army Research Office (TMS), by NIH through grant EB00768 (BJB).

Abstract

original image

Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid-β plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported.

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