F.Z. and Q.Z. contributed equally. This work was supported in part by the National Institutes of Health (Grant AI51104 to T.H. and AI47673 to Y.T.). We thank Dr. Daniel Wall and Ms. Jamie Froelich for antibacterial testing.
Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative†
Article first published online: 22 JUL 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 33, pages 5329–5334, August 19, 2005
How to Cite
Zhao, F., Zhao, Q., Blount, K. F., Han, Q., Tor, Y. and Hermann, T. (2005), Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative. Angew. Chem. Int. Ed., 44: 5329–5334. doi: 10.1002/anie.200500903
- Issue published online: 15 AUG 2005
- Article first published online: 22 JUL 2005
- Manuscript Revised: 22 APR 2005
- Manuscript Received: 11 MAR 2005
- RNA recognition;
- X-ray crystallography
The preorganized presentation of functional groups in the antibiotic neomycin (green) is exploited to obtain a conformationally restricted aminoglycoside (yellow) by regioselective intramolecular cyclization. X-ray crystallography data show how the natural product and the derivative recognize the RNA target motif that is the binding site of aminoglycoside antibiotics.