SEARCH

SEARCH BY CITATION

Keywords:

  • aptamers;
  • biosensors;
  • DNA structures;
  • electron transfer;
  • thrombin
Thumbnail image of graphical abstract

Blue, gold, and DNA: A methylene blue (MB) tagged, thrombin-binding DNA aptamer immobilized on a gold surface undergoes a large conformational change upon target binding (see schematic representation; eT: electron transfer). This folding produces a large, readily measurable change in redox current and allows the electrochemical detection of thrombin in blood serum.