Copyright© The Nobel Foundation 2004. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
Ubiquitin at Fox Chase (Nobel Lecture)†
Article first published online: 5 SEP 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 37, pages 5926–5931, September 19, 2005
How to Cite
Rose, I. (2005), Ubiquitin at Fox Chase (Nobel Lecture). Angew. Chem. Int. Ed., 44: 5926–5931. doi: 10.1002/anie.200500995
- Issue published online: 14 SEP 2005
- Article first published online: 5 SEP 2005
- Manuscript Received: 18 MAR 2005
- Nobel lecture;
- protein breakdown;
Protein breakdown is an exact, controlled process in which the protein molecule ubiquitin plays a decisive role by binding to a protein and labeling it for breakdown. The cellular mechanisms of this process are widely known today thanks to the work of the 2004 Nobel Laureates Irwin Rose, Avram Hershko, and Aaron Ciechanover. The Laureates report at first hand in their Nobel Lectures.