Ubiquitin at Fox Chase (Nobel Lecture)


  • Copyright© The Nobel Foundation 2004. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.


Protein breakdown is an exact, controlled process in which the protein molecule ubiquitin plays a decisive role by binding to a protein and labeling it for breakdown. The cellular mechanisms of this process are widely known today thanks to the work of the 2004 Nobel Laureates Irwin Rose, Avram Hershko, and Aaron Ciechanover. The Laureates report at first hand in their Nobel Lectures.