We gratefully acknowledge support for this work from the U.S. NIH (EB00549-5). We thank Dr. Lara Mahal for her advice and insight. Thanks also to Dr. Klaus Linse and Michelle Gadush for their assistance in sequencing beads.
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Communication
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Differential Receptors Create Patterns That Distinguish Various Proteins†
Article first published online: 12 SEP 2005
DOI: 10.1002/anie.200501137
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wright, A. T., Griffin, M. J., Zhong, Z., McCleskey, S. C., Anslyn, E. V. and McDevitt, J. T. (2005), Differential Receptors Create Patterns That Distinguish Various Proteins. Angew. Chem. Int. Ed., 44: 6375–6378. doi: 10.1002/anie.200501137
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Publication History
- Issue published online: 30 SEP 2005
- Article first published online: 12 SEP 2005
- Manuscript Revised: 6 JUN 2005
- Manuscript Received: 30 MAR 2005
Keywords:
- host–guest systems;
- proteins;
- receptors;
- supramolecular chemistry
Pattern formation: Analysis with an array of differential receptors such as 1 rather than specific receptors leads to patterns for various proteins and glycoproteins that can be examined by principal component analysis. This allows for the direct recognition of large substrates for which the creation of synthetic specific receptors would be very difficult.