We thank Professor Paul Knochel, the DFG (Emmy Noether-Programm), the Fonds der Chemischen Industrie, and the Ludwig-Maximilians-Universität for generous support.
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Communication
Titanium-Catalyzed Intermolecular Hydroamination of Vinylarenes†
Article first published online: 12 AUG 2005
DOI: 10.1002/anie.200501423
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 44, Issue 37, pages 5972–5974, September 19, 2005
Additional Information
How to Cite
Kaspar, L. T., Fingerhut, B. and Ackermann, L. (2005), Titanium-Catalyzed Intermolecular Hydroamination of Vinylarenes. Angewandte Chemie International Edition, 44: 5972–5974. doi: 10.1002/anie.200501423
- †
Publication History
- Issue published online: 14 SEP 2005
- Article first published online: 12 AUG 2005
- Manuscript Received: 25 APR 2005
Keywords:
- alkenes;
- catalysis;
- heterocycles;
- hydroamination;
- titanium
Graphical Abstract
The Lewis acid TiCl4 allows the intermolecular hydroamination of vinylarenes (see scheme). Some of the hydroamination products undergo rearrangements to give ortho-alkylated compounds. The catalyst tolerates a range of functional groups (R′=CF3, Cl, CN, F, Br) and provides the products in good yields. This method was also applied to the synthesis of a tetrahydroisoquinoline derivative.