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A Highly DNA-Duplex-Stabilizing Metal–Salen Base Pair

Authors

  • Guido H. Clever Dipl.-Chem.,

    1. Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, Butenandtstrasse 5–13, Haus F, 81377 München, Germany, Fax: (+49) 89-2180-77756
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  • Kurt Polborn Dr.,

    1. Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, Butenandtstrasse 5–13, Haus F, 81377 München, Germany, Fax: (+49) 89-2180-77756
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  • Thomas Carell Prof. Dr.

    1. Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, Butenandtstrasse 5–13, Haus F, 81377 München, Germany, Fax: (+49) 89-2180-77756
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  • This research was supported by the Volkswagen Foundation and the Deutsche Forschungsgemeinschaft (research group: Hybrid Compounds) and by the Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie e.V. (Kekulé fellowship to G.C.). We thank Prof. P. Klüfers for helpful discussions and Heather Burks, Tanja Köpping, Kirsten Schwekendiek, and Michaela Vedecnik for assistance in synthesis.

Abstract

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Stabilizing influence: When a DNA duplex containing two salicylic aldehyde nucleosides facing each other is treated with ethylenediamine and one equivalent of a Cu2+ or Mn2+ salt, a metal–salen base pair is formed within the DNA. The resulting stabilization of the DNA structure is attributed to the cross-linking of the salicylic aldehyde units with ethylenediamine.

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