Communication

Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes†

  1. Wei Wu Dr.1,
  2. Sébastien Wieckowski1,
  3. Giorgia Pastorin Dr.1,
  4. Monica Benincasa Dr.3,
  5. Cédric Klumpp1,2,
  6. Jean-Paul Briand Dr.1,
  7. Renato Gennaro Prof.3,
  8. Maurizio Prato Prof.2,
  9. Alberto Bianco Dr.1

Article first published online: 2 SEP 2005

DOI: 10.1002/anie.200501613

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 44, Issue 39, pages 6358–6362, October 7, 2005

Additional Information

How to Cite

Wu, W., Wieckowski, S., Pastorin, G., Benincasa, M., Klumpp, C., Briand, J.-P., Gennaro, R., Prato, M. and Bianco, A. (2005), Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes. Angew. Chem. Int. Ed., 44: 6358–6362. doi: 10.1002/anie.200501613

Author Information

  1. 1

    Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680

  2. 2

    Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy

  3. 3

    Dipartimento di Biochimica, Biofisica e Chimica Macromoleculare, Università di Trieste, 34127 Trieste, Italy

  1. †

    This work was financially supported by the CNRS, the University of Trieste, and the MIUR (PRIN 2004, prot. 2004035502). W.W. and G.P. are grateful to the French Ministry for Research and New Technologies for a post doctoral fellowship. The authors wish to thank Sylvie Fournel for critical reading of this manuscript.

Publication History

  1. Issue published online: 30 SEP 2005
  2. Article first published online: 2 SEP 2005
  3. Manuscript Revised: 26 JUL 2005
  4. Manuscript Received: 11 MAY 2005

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Keywords:

  • antibiotics;
  • drug delivery;
  • nanotubes;
  • nanovectors;
  • toxicity
Thumbnail image of graphical abstract

Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.

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