This work was financially supported by the CNRS, the University of Trieste, and the MIUR (PRIN 2004, prot. 2004035502). W.W. and G.P. are grateful to the French Ministry for Research and New Technologies for a post doctoral fellowship. The authors wish to thank Sylvie Fournel for critical reading of this manuscript.
Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes†
Article first published online: 2 SEP 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 39, pages 6358–6362, October 7, 2005
How to Cite
Wu, W., Wieckowski, S., Pastorin, G., Benincasa, M., Klumpp, C., Briand, J.-P., Gennaro, R., Prato, M. and Bianco, A. (2005), Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes. Angew. Chem. Int. Ed., 44: 6358–6362. doi: 10.1002/anie.200501613
- Issue published online: 30 SEP 2005
- Article first published online: 2 SEP 2005
- Manuscript Revised: 26 JUL 2005
- Manuscript Received: 11 MAY 2005
- drug delivery;
Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.