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Targeted Delivery of Amphotericin B to Cells by Using Functionalized Carbon Nanotubes

Authors

  • Wei Wu Dr.,

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
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  • Sébastien Wieckowski,

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
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  • Giorgia Pastorin Dr.,

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
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  • Monica Benincasa Dr.,

    1. Dipartimento di Biochimica, Biofisica e Chimica Macromoleculare, Università di Trieste, 34127 Trieste, Italy
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  • Cédric Klumpp,

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
    2. Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy
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  • Jean-Paul Briand Dr.,

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
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  • Renato Gennaro Prof.,

    1. Dipartimento di Biochimica, Biofisica e Chimica Macromoleculare, Università di Trieste, 34127 Trieste, Italy
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  • Maurizio Prato Prof.,

    1. Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste, Italy
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  • Alberto Bianco Dr.

    1. Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, Fax: (+33) 3-8861-0680
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  • This work was financially supported by the CNRS, the University of Trieste, and the MIUR (PRIN 2004, prot. 2004035502). W.W. and G.P. are grateful to the French Ministry for Research and New Technologies for a post doctoral fellowship. The authors wish to thank Sylvie Fournel for critical reading of this manuscript.

Abstract

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Tasty tubes: Multiwalled carbon nanotubes functionalized with fluorescein isothiocyanate and amphotericin B (AmB) have been shown to be rapidly internalized by mammalian cells (see picture) without the toxic effects typically displayed upon treatment with AmB. Furthermore, the modified drug exhibits a higher antifungal activity than native AmB.

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