A Sensitive Colorimetric and Fluorescent Probe Based on a Polythiophene Derivative for the Detection of ATP



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From amber to red: The water-soluble polythiophene derivative 1 forms a supramolecular complex with ATP (adenosine triphosphate) through electrostatic and hydrophobic cooperative interactions which results in a color change of the aqueous solution from yellow to pink-red (see photo; AMP/ADP=adenosine mono-/diphosphate). Besides naked-eye detection of ATP, the detection limit may be extended to 10−8M by using fluorometry.