This research was supported by Prof. Paul Knochel, the DFG (Emmy Noether-Programm), the Fonds der Chemischen Industrie, and the Ludwig-Maximilians-Universität.
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Communication
Efficient Aryl–(Hetero)Aryl Coupling by Activation of C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
Cl and CF Bonds Using Nickel Complexes of Air-Stable Phosphine Oxides†
Article first published online: 17 OCT 2005
DOI: 10.1002/anie.200501860
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 44, Issue 44, pages 7216–7219, November 11, 2005
Additional Information
How to Cite
Ackermann, L., Born, R., Spatz, J. H. and Meyer, D. (2005), Efficient Aryl–(Hetero)Aryl Coupling by Activation of CCl and CF Bonds Using Nickel Complexes of Air-Stable Phosphine Oxides. Angewandte Chemie International Edition, 44: 7216–7219. doi: 10.1002/anie.200501860
- †
Publication History
- Issue published online: 8 NOV 2005
- Article first published online: 17 OCT 2005
- Manuscript Received: 29 MAY 2005
Keywords:
- CC coupling;
- CF activation;
- Grignard reaction;
- nickel;
- phosphine oxides
Graphical Abstract
A couple of couplings: Air-stable diamino- and dioxophosphine oxides are used as preligands in the nickel-catalyzed Kumada cross-coupling reactions of aryl Grignard reagents. A sterically hindered preligand allows for highly efficient cross-coupling of aryl fluorides at ambient temperature (acac=acetylacetonate).