Both authors contributed equally to the work.
Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology†
Article first published online: 8 NOV 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 47, pages 7764–7767, December 2, 2005
How to Cite
Klein, G., Humbert, N., Gradinaru, J., Ivanova, A., Gilardoni, F., Rusbandi, U. E. and Ward, T. R. (2005), Tailoring the Active Site of Chemzymes by Using a Chemogenetic-Optimization Procedure: Towards Substrate-Specific Artificial Hydrogenases Based on the Biotin–Avidin Technology. Angew. Chem. Int. Ed., 44: 7764–7767. doi: 10.1002/anie.200502000
We thank Professor C. R. Cantor for the streptavidin gene and Professors P. Schürmann and J.-M. Neuhaus for their help in setting up the protein production. This work was funded by the Swiss National Science Foundation (Grants FN 620-57866.99 and FN 200021-105192/1 as well as NRP 47 “Supramolecular Functional Materials”), CERC3 (Grant FN20C321-101071), the Roche Foundation, the Canton of Neuchâtel, as well as the FP6 Marie Curie Research Training Network (MRTN-CT-2003-505020). Umicore Precious Metals Chemistry is acknowledged for a loan of rhodium.
- Issue published online: 28 NOV 2005
- Article first published online: 8 NOV 2005
- Manuscript Revised: 11 SEP 2005
- Manuscript Received: 10 JUN 2005
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