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General Catalysts for the Suzuki–Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water


  • We thank the National Institutes of Health (GM 46059 and GM 1S10RR13886-01) and the National Cancer Institute (Cancer Training Grant GM 5-T32-CAO9112-30) for support of this work. We are grateful to Merck, Englehard (Pd(OAc)2), and CEM (microwave reactor and supplies) for additional support.


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Amphiphilic phosphine ligands (see structures; Cy=cyclohexyl) were prepared and utilized in palladium-catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water or water/organic biphasic solvents, providing excellent yields of functionalized biaryls and aryl alkynes, respectively.