This work was funded through the National Science Foundation (NSF-DMR0317514) and the Department of Energy (DE-AC03-76SF00098). Dr. Jeffrey Pyun contributed to early exploratory work on this project.
One-Pot Reaction Cascades Using Star Polymers with Core-Confined Catalysts†
Article first published online: 14 SEP 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 44, Issue 39, pages 6384–6387, October 7, 2005
How to Cite
Helms, B., Guillaudeu, S. J., Xie, Y., McMurdo, M., Hawker, C. J. and Fréchet, J. M. J. (2005), One-Pot Reaction Cascades Using Star Polymers with Core-Confined Catalysts. Angew. Chem. Int. Ed., 44: 6384–6387. doi: 10.1002/anie.200502095
- Issue published online: 30 SEP 2005
- Article first published online: 14 SEP 2005
- Manuscript Received: 16 JUN 2005
- homogeneous catalysis;
- reaction cascades
My stars! Star polymers that contain otherwise incompatible acid or base catalysts, such as para-toluenesulfonic acid or 4-(dialkylamino)pyridines moieties, at their sterically restricted cores (see scheme) are readily prepared. Homogeneous catalysis using these star polymers can perform reaction cascades in the same pot and is demonstrated with an acid-catalyzed deprotection and the nucleophilic amine-catalyzed Baylis–Hillman reaction.