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One-Pot Reaction Cascades Using Star Polymers with Core-Confined Catalysts


  • This work was funded through the National Science Foundation (NSF-DMR0317514) and the Department of Energy (DE-AC03-76SF00098). Dr. Jeffrey Pyun contributed to early exploratory work on this project.


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My stars! Star polymers that contain otherwise incompatible acid or base catalysts, such as para-toluenesulfonic acid or 4-(dialkylamino)pyridines moieties, at their sterically restricted cores (see scheme) are readily prepared. Homogeneous catalysis using these star polymers can perform reaction cascades in the same pot and is demonstrated with an acid-catalyzed deprotection and the nucleophilic amine-catalyzed Baylis–Hillman reaction.