Architecture and Evolution of Organic Chemistry

Authors

  • Marcin Fialkowski Dr.,

    1. Department of Chemical and Biological Engineering and Northwestern Institute of Complexity, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA, Fax: (+1) 847-491-3728
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  • Kyle J. M. Bishop,

    1. Department of Chemical and Biological Engineering and Northwestern Institute of Complexity, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA, Fax: (+1) 847-491-3728
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  • Victor A. Chubukov,

    1. Department of Chemical and Biological Engineering and Northwestern Institute of Complexity, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA, Fax: (+1) 847-491-3728
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  • Christopher J. Campbell,

    1. Department of Chemical and Biological Engineering and Northwestern Institute of Complexity, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA, Fax: (+1) 847-491-3728
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  • Bartosz A. Grzybowski Prof. Dr.

    1. Department of Chemical and Biological Engineering and Northwestern Institute of Complexity, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA, Fax: (+1) 847-491-3728
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  • B.A.G. gratefully acknowledges financial support from the Camille and Henry Dreyfus New Faculty Awards Program. K.J.M.B. and C.J.C. were supported in part by the NSF-IGERT program “Dynamics of Complex Systems in Science and Engineering” (DGE-9987577).

Abstract

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Organic syntheses reported in the literature between 1850 and 2000 are analyzed at the simplified level of a connected network (see the picture of the network for 1850). Fundamental statistical laws that govern organic syntheses are established. These laws allow the estimation of the synthetic and industrial usefulness of organic molecules.

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