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Keywords:

  • cell adhesion;
  • chemical biology;
  • DNA recognition;
  • glycoproteins;
  • Staudinger ligation
Thumbnail image of graphical abstract

Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.