Communication

Programmable Cell Adhesion Encoded by DNA Hybridization†

  1. Ravi A. Chandra3,
  2. Erik S. Douglas4,
  3. Richard A. Mathies Prof.5,6,
  4. Carolyn R. Bertozzi Prof.7,8,9,
  5. Matthew B. Francis Prof.1,2

Article first published online: 21 DEC 2005

DOI: 10.1002/anie.200502421

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 45, Issue 6, pages 896–901, January 30, 2006

Additional Information

How to Cite

Chandra, R. A., Douglas, E. S., Mathies, R. A., Bertozzi, C. R. and Francis, M. B. (2006), Programmable Cell Adhesion Encoded by DNA Hybridization. Angew. Chem. Int. Ed., 45: 896–901. doi: 10.1002/anie.200502421

Author Information

  1. 1

    Department of Chemistry, University of California, Berkeley

  2. 2

    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Fax: (+1) 510-643-3079

  3. 3

    Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA

  4. 4

    UCB/UCSF Joint Graduate Group in Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA

  5. 5

    Department of Chemistry and UCB/UCSF Joint Graduate Group in Bioengineering, University of California, Berkeley

  6. 6

    Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

  7. 7

    Departments of Chemistry & Molecular and Cell Biology

  8. 8

    Howard Hughes Medical Institute, University of California, Berkeley

  9. 9

    Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

  1. †

    The authors thank H. Lee, J. Prescher, M. Hangauer, and N. Toriello for helpful discussions and assistance. R.A.C. and E.S.D. were supported by National Science Foundation Predoctoral Fellowships. This work was supported by generous financial support from the Nanoscale Science, Energy, and Technology (NSET) Program of the Department of Energy.

Publication History

  1. Issue published online: 23 JAN 2006
  2. Article first published online: 21 DEC 2005
  3. Manuscript Revised: 7 NOV 2005
  4. Manuscript Received: 12 JUL 2005

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Keywords:

  • cell adhesion;
  • chemical biology;
  • DNA recognition;
  • glycoproteins;
  • Staudinger ligation
Thumbnail image of graphical abstract

Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

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