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Sequential Self-Assembly of a DNA Hexagon as a Template for the Organization of Gold Nanoparticles


  • This work was supported by the NSERC, the Canada Foundation for Innovation, Nanoquebec, Research Corporation, the Center for Self-Assembled Chemical Structures, and the NSERC Strategic Grant Program. We thank Antisar R. Hlil for MALDI-TOF MS measurements. H.F.S. is a Cottrell Scholar of the Research Corporation.


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Six of one and half a dozen of the other: A cyclic hexamer of six gold nanoparticles was sequentially and selectively self-assembled by labeling each particle (red sphere) with a DNA-containing molecule (colored block), which serves to dictate its ultimate location within the final construct. This method may be used to construct any discrete well-defined pattern of nanoparticles.

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