We thank the Fonds der Chemischen Industrie and Merck Research Laboratories (MSD) for financial support. We also thank Chemetall, BASF, and Bayer Chemicals for generous gifts of chemicals. Ln=La, Ce, Nd.
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Communication
Soluble Lanthanide Salts (LnCl3⋅2 LiCl) for the Improved Addition of Organomagnesium Reagents to Carbonyl Compounds†
Article first published online: 5 JAN 2006
DOI: 10.1002/anie.200502485
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Krasovskiy, A., Kopp, F. and Knochel, P. (2006), Soluble Lanthanide Salts (LnCl3⋅2 LiCl) for the Improved Addition of Organomagnesium Reagents to Carbonyl Compounds. Angew. Chem. Int. Ed., 45: 497–500. doi: 10.1002/anie.200502485
- †
Publication History
- Issue published online: 5 JAN 2006
- Article first published online: 5 JAN 2006
- Manuscript Revised: 29 SEP 2005
- Manuscript Received: 16 JUL 2005
Keywords:
- 1,2-additions;
- enols;
- Grignard reaction;
- imines;
- lanthanides
Easy-to-prepare solutions of LnCl3⋅2 LiCl (Ln=La, Ce, Nd) (0.3–0.5 M in THF) are a unique source of soluble lanthanide salts with versatile applications in organic synthesis. These salts can serve as promoters or catalysts for the addition of organometallic compounds to sterically hindered, enolizable or α,β-unsaturated ketones or imines.