This research was supported by the ETH Zürich, by a Feodor Lynen Research Fellowship of the Alexander von Humboldt Foundation, and by an Emmy Noether Fellowship of the Deutsche Forschungsgemeinschaft (to D.B.W.). We thank Prof. Dr. B. Jaun and B. Brandenberg for NMR measurements.
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Communication
Total Synthesis of Antigen Bacillus Anthracis Tetrasaccharide—Creation of an Anthrax Vaccine Candidate†
Article first published online: 19 SEP 2005
DOI: 10.1002/anie.200502615
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Werz, D. B. and Seeberger, P. H. (2005), Total Synthesis of Antigen Bacillus Anthracis Tetrasaccharide—Creation of an Anthrax Vaccine Candidate. Angew. Chem. Int. Ed., 44: 6315–6318. doi: 10.1002/anie.200502615
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Publication History
- Issue published online: 30 SEP 2005
- Article first published online: 19 SEP 2005
- Manuscript Received: 26 JUL 2005
Keywords:
- anthrose;
- carbohydrates;
- oligosaccharides;
- total synthesis;
- vaccines
Fighting Anthrax by recognizing its coat: The spores of Bacillus anthracis bear unique oligosaccharides on their surface for interaction with a host. These specific oligosaccharides may prove useful in the development of vaccines against this major biowarfare threat. The total synthesis of such a vaccine candidate (see picture, Pent=4-pentenyl) is reported.