Programmable Ligand-Controlled Riboregulators


  • The author acknowledges the Austrian Science Fund (FWF) for generous funding and Claudia Höbartner for critical reading of the manuscript.


original image

A flexible platform for control of gene expression is represented by rationally designed antiswitches. These trans-acting riboregulators consist of an antisense domain and an aptamer domain. They are responsive to small ligands, modular, and fully tunable to target any gene of interest (see picture).