Programmable Ligand-Controlled Riboregulators

Authors


  • The author acknowledges the Austrian Science Fund (FWF) for generous funding and Claudia Höbartner for critical reading of the manuscript.

Abstract

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A flexible platform for control of gene expression is represented by rationally designed antiswitches. These trans-acting riboregulators consist of an antisense domain and an aptamer domain. They are responsive to small ligands, modular, and fully tunable to target any gene of interest (see picture).

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