This investigation was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (16206078). We thank the center of excellence (21COE; program “Creation of Integrated Ecochemistry”, Osaka University) and Dr. Uruga (Spring-8) for X-ray absorption fine-structure (XAFS) measurements.
Convenient and Efficient Pd-Catalyzed Regioselective Oxyfunctionalization of Terminal Olefins by Using Molecular Oxygen as Sole Reoxidant†
Article first published online: 2 DEC 2005
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 3, pages 481–485, January 9, 2006
How to Cite
Mitsudome, T., Umetani, T., Nosaka, N., Mori, K., Mizugaki, T., Ebitani, K. and Kaneda, K. (2006), Convenient and Efficient Pd-Catalyzed Regioselective Oxyfunctionalization of Terminal Olefins by Using Molecular Oxygen as Sole Reoxidant. Angew. Chem. Int. Ed., 45: 481–485. doi: 10.1002/anie.200502886
- Issue published online: 5 JAN 2006
- Article first published online: 2 DEC 2005
- Manuscript Received: 13 AUG 2005
- Wacker oxidation
Just the one: The combination of palladium dichloride and N,N-dimethylacetamide (DMA) constitutes a highly efficient and reusable catalytic system, which uses molecular oxygen as the sole reoxidant for liquid-phase Wacker oxidation and acetoxylation of terminal olefins to the corresponding methyl ketones and linear allylic acetates, respectively (see scheme).