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Keywords:

  • DNA;
  • fluorescence microscopy;
  • gene expression;
  • intracellular transport;
  • nanoparticles
Thumbnail image of graphical abstract

Tracking transport: Cationic polyethylenimine nanoparticles serve as nonviral vectors and deliver DNA to the nucleus of cells. Fluorescence live-cell imaging highlights the interactions between these polyplexes and the cytoskeleton during the subsequent stages of transfection (see picture). The analysis of the underlying transport processes gives new impulse to further chemical-synthesis approaches.