Copper-in-Charcoal (Cu/C): Heterogeneous, Copper-Catalyzed Asymmetric Hydrosilylations


  • We warmly thank the NSF (CHE 0213522) for financial support, and Dr. Louise Weaver of the Microscopy and Microanalysis Facility at the University of New Brunswick for the surface analyses ( We are also indebted to Dr. Takao Saito and Mr. Hideo Shimizu (Takasago, Co.), Drs. R. Schmid and M. Scalone (Roche, Basel), and Drs. H.-U. Blaser and M. Thommen (Solvias) for supplying the segphos, biphep, and josiphoss ligands, respectively, used in this study. We thank Ms. Danielle Nihan for providing unsaturated lactone 2.


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Asymmetric copper chemistry … done heterogeneously? It's doable: Copper-in-charcoal (Cu/C) is introduced as an easily prepared catalyst that is readily converted in situ into a nonracemically ligated form of copper hydride that effects asymmetric hydrosilylations. DTBM=3,5-di-tert-butyl-4-methoxydiphenylphosphinyl.