syn- oranti-pathy? Determination of the relative configuration of the α-methylene-γ-butyrolactone 1 failed by conventional NMR methods, because structures in the conformational space of both diastereoisomers exist that fulfill the restraints from NOE and 3J coupling data equally well. Homo- and heteronuclear residual dipolar couplings were measured which indicate that 1 is trans configured.
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