This work was supported by The National Science Foundation (MCB-0209769).
An Arabidopsis Oxidosqualene Cyclase Catalyzes Iridal Skeleton Formation by Grob Fragmentation†
Article first published online: 19 JAN 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 8, pages 1285–1288, February 13, 2006
How to Cite
Xiong, Q., Wilson, W. K. and Matsuda, S. P. T. (2006), An Arabidopsis Oxidosqualene Cyclase Catalyzes Iridal Skeleton Formation by Grob Fragmentation. Angew. Chem. Int. Ed., 45: 1285–1288. doi: 10.1002/anie.200503420
- Issue published online: 6 FEB 2006
- Article first published online: 19 JAN 2006
- Manuscript Received: 28 SEP 2005
Mechanistic and phylogenetic surprises: A triterpene synthase (MRN1) from Arabidopsis invokes a Grob fragmentation in the cyclization of oxidosqualene. The enzymatic product is the elusive carbocyclic precursor of iridals, unusual triterpenoids known only in the distant Iris family. The results demonstrate the power of genome mining and exemplify the facile evolution of cyclases to generate diverse triterpene skeletons.