Angewandte Chemie International Edition
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Communication
A Striking Periodicity of the cis/trans Isomerization of Proline Imide Bonds in Cyclic Disulfide-Bridged Peptides†
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This work was supported in part by National Institutes of Health grant GM 37000.
Abstract

cispersists: The population of the cis conformation of the Cys–Pro imide bond of the cyclic disulfide form of peptides of the sequence Ac-Cys-Pro-(Xaa)m-Cys-NH2 (Xaa=Phe, Ala) ranges from 9.3 to 76.9 % and shows a striking periodic dependence on the number of residues in the peptide.