Chiral Polyesters by Dynamic Kinetic Resolution Polymerization


  • This work was supported in part by the Marie Curie Action RTN program “Biocatalytic Approach to Material Design” (BIOMADE; I.H. contract no. MRTN-CT-2004-505147) and by the NWO (grant to A.R.A.P.).


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Problem resolved: Enzymatic polymerization was combined with an in situ Ru-catalyzed racemization process. The reaction mixture comprises a racemic mixture of a chiral diol and dimethyl adipate. Because of the high stereoselectivity of the enzyme Candida antarctica lipase B (CALB), the S-configured stereocenters of the chiral diol are practically nonreactive. Polycondensation was achieved by concurrent racemization of the S- into the R-configured centers.