Droplet-Based DNA Purification in a Magnetic Lab-on-a-Chip


  • We thank the Swiss National Science Foundation (Grant 200020-107372) for financial support of this research. We also acknowledge Dr. A. Rida and S. Hadjidj for their advice and support in the initial phase of the project, M. Friedrich for assistance with the experiments, A. Tschersich for determination of the oil properties, and F. Fenter for critical reading of the manuscript.


original image

Merge, mix, split, and transport are the main manipulation steps used for on-chip droplet-based DNA purification (see figure). The system is able to extract genomic material from dilute raw cell samples by using the actuation of magnetic microparticles within the droplets through a matrix of coils.