Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate

Authors

  • Xiao-Bin Jiang Dr.,

    1. Homogeneous Catalysis van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, Fax: (+31) 20-525-6422
    Search for more papers by this author
  • Laurent Lefort Dr.,

    1. DSM research, DSM Pharma Chemicals, Advanced Synthesis, Catalysis & Development, P. O. Box 18, 6160 MD Geleen, The Netherlands
    Search for more papers by this author
  • P. Elsbeth Goudriaan,

    1. Homogeneous Catalysis van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, Fax: (+31) 20-525-6422
    Search for more papers by this author
  • André H. M. de Vries Dr.,

    1. DSM research, DSM Pharma Chemicals, Advanced Synthesis, Catalysis & Development, P. O. Box 18, 6160 MD Geleen, The Netherlands
    Search for more papers by this author
  • Piet W. N. M. van Leeuwen Prof. Dr.,

    1. Homogeneous Catalysis van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, Fax: (+31) 20-525-6422
    Search for more papers by this author
  • Johannes G. de Vries Prof. Dr.,

    1. DSM research, DSM Pharma Chemicals, Advanced Synthesis, Catalysis & Development, P. O. Box 18, 6160 MD Geleen, The Netherlands
    Search for more papers by this author
  • Joost N. H. Reek Dr.

    1. Homogeneous Catalysis van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, Fax: (+31) 20-525-6422
    Search for more papers by this author

  • This work was financially supported by NWO.

Abstract

original image

Bindings for libraries: Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc(II) porphyrin and the other on a substituted phosphane) by using high-throughput methods combined with self-assembly principles. The library provided a Rh catalyst that hydrogenates the enamide 1 with the highest enantioselectivity known to date.

Ancillary