A Dynamic Kinetic Resolution of Allyl Alcohols by the Combined Use of Lipases and [VO(OSiPh3)3]


  • This work was supported by Grants-in-Aid for Scientific Research (S and C) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. We thank Roche Diagnostics K. K., Japan and Amano Enzyme Inc., Japan for the generous gift of the lipases.


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Mix and match: A new type of dynamic kinetic resolution of racemic allyl alcohols uses a combination of lipases and [VO(OSiPh3)3] (1). The 1,3-transposition of allyl alcohols catalyzed by 1 gave thermodynamic mixtures of two regioisomers, which underwent highly enantio- and chemoselective esterification with lipases. Optically enriched allyl acetates were isolated in high yields.