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Keywords:

  • allyl alcohols;
  • asymmetric synthesis;
  • dynamic kinetic resolution;
  • lipases;
  • vanadium
Thumbnail image of graphical abstract

Mix and match: A new type of dynamic kinetic resolution of racemic allyl alcohols uses a combination of lipases and [VO(OSiPh3)3] (1). The 1,3-transposition of allyl alcohols catalyzed by 1 gave thermodynamic mixtures of two regioisomers, which underwent highly enantio- and chemoselective esterification with lipases. Optically enriched allyl acetates were isolated in high yields.