This work was supported by the Université Catholique de Louvain. Dr. B. Pugin (Solvias) and Dr. R. Schmid (Hoffmann–La Roche) are gratefully acknowledged for generous gifts of chiral ligands. Mr. V. Van Tran is also acknowledged for his assistance with the chiral analysis of the new compounds.
Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate†
Article first published online: 20 JAN 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 45, Issue 8, pages 1292–1297, February 13, 2006
How to Cite
Deschamp, J., Chuzel, O., Hannedouche, J. and Riant, O. (2006), Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate. Angew. Chem. Int. Ed., 45: 1292–1297. doi: 10.1002/anie.200503791
- Issue published online: 6 FEB 2006
- Article first published online: 20 JAN 2006
- Manuscript Received: 26 OCT 2005
- aldol reaction;
A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo-, diastereo-, and enantioselectivity.