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Keywords:

  • aldol reaction;
  • copper;
  • enantioselectivity;
  • enolates;
  • hydrosilylation
Thumbnail image of graphical abstract

A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo-, diastereo-, and enantioselectivity.