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A Catalytic Approach for the Functionalization of C(sp3)[BOND]H Bonds

  1. Mamoru Tobisu Dr.,
  2. Naoto Chatani Prof. Dr.

Article first published online: 21 FEB 2006

DOI: 10.1002/anie.200503866

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 45, Issue 11, pages 1683–1684, March 6, 2006

Additional Information

How to Cite

Tobisu, M. and Chatani, N. (2006), A Catalytic Approach for the Functionalization of C(sp3)[BOND]H Bonds. Angew. Chem. Int. Ed., 45: 1683–1684. doi: 10.1002/anie.200503866

Author Information

  1. Department of Applied Chemisry, Osaka University, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-7396

Publication History

  1. Issue published online: 1 MAR 2006
  2. Article first published online: 21 FEB 2006

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Keywords:

  • 1,5-hydride shift;
  • C[BOND]H activation;
  • catalysis;
  • Lewis acids
Thumbnail image of graphical abstract

Access allowed: A Lewis acid catalyzed 1,5-hydride shift is the key step in the direct functionalization of sterically congested C(sp3)[BOND]H bonds. This new method complements the existing transition-metal-mediated reactions that are limited to the functionalization of more accessible C[BOND]H bonds.

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