Communication

Solving the Clogging Problem: Precipitate-Forming Reactions in Flow†

  1. Sarah L. Poe1,
  2. Meredith A. Cummings2,
  3. Michael P. Haaf Prof.2,
  4. D. Tyler McQuade Prof.1

Article first published online: 13 JAN 2006

DOI: 10.1002/anie.200503925

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 45, Issue 10, pages 1544–1548, February 27, 2006

Additional Information

How to Cite

Poe, S. L., Cummings, M. A., Haaf, M. P. and McQuade, D. T. (2006), Solving the Clogging Problem: Precipitate-Forming Reactions in Flow. Angew. Chem. Int. Ed., 45: 1544–1548. doi: 10.1002/anie.200503925

Author Information

  1. 1

    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA, Fax: (+1) 607-255-4137

  2. 2

    Chemistry Department, Center for Natural Sciences, Ithaca College, Ithaca, NY 14850, USA

  1. †

    This work was supported by NSF Sensors (CTS-0329899), ARO MAP-MURI, Cornell Center for Materials Science, and the Beckman Foundation.

Publication History

  1. Issue published online: 20 FEB 2006
  2. Article first published online: 13 JAN 2006
  3. Manuscript Received: 5 NOV 2005

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Keywords:

  • aldol reaction;
  • flow reactions;
  • microreactors;
  • synthesis design
Thumbnail image of graphical abstract

Solids go with the flow: A monodisperse flow in a microreactor provides an efficient method for keeping solid products away from channel walls. The use of a carrier phase, such as mineral oil, hexane, or toluene, enables solids to be synthesized without clogging of the reactor channels. Further injection points can be added to the microreactor to perform multistep syntheses (see picture).

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