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Keywords:

  • amides;
  • chemoselectivity;
  • ketoacids;
  • ligation reactions;
  • peptides
Thumbnail image of graphical abstract

Additive-free: The chemoselective amide-bond-forming ligation between N-alkylhydroxylamines and α-ketoacids requires no reagents and the only by-products are water and carbon dioxide. This process proceeds on unprotected peptide substrates without epimerization, and as such, this process has the potential to serve as a novel chemoselective ligation for the synthesis of peptides and complex materials.