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A Biocatalytic Henry Reaction—The Hydroxynitrile Lyase from Hevea brasiliensis Also Catalyzes Nitroaldol Reactions


  • We thank Prof. Bernard Golding, University of Newcastle, for his fruitful contributions to this project. The Österreichische Forschungsförderungsgesellschaft (FFG), the Province of Styria and the Styrian Business Promotion Agency (SFG), and the city of Graz—within the framework of the Kplus programme—are acknowledged for financial support.


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Novel enzyme activity: Biocatalytic Henry reactions with nitromethane and nitroethane yielded the corresponding nitroalcohols with good enantio- and diastereocontrol in the presence of the hydroxynitrile lyase from the tropical rubber tree Hevea brasiliensis. Molecular modeling and deuterated starting materials were used in mechanistic investigations.