We thank the EPSRC for a studentship to A.R.G.
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Essay
Stereochemical Uniformity in Marine Polyether Ladders—Implications for the Biosynthesis and Structure of Maitotoxin†
Article first published online: 12 JUN 2006
DOI: 10.1002/anie.200504284
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Gallimore, A. R. and Spencer, J. B. (2006), Stereochemical Uniformity in Marine Polyether Ladders—Implications for the Biosynthesis and Structure of Maitotoxin. Angew. Chem. Int. Ed., 45: 4406–4413. doi: 10.1002/anie.200504284
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Publication History
- Issue published online: 28 JUN 2006
- Article first published online: 12 JUN 2006
- Manuscript Received: 2 DEC 2005
Keywords:
- antibiotic;
- biosynthesis;
- epoxidation;
- polyether ladders;
- polyketide synthase
Odd one out: Marine polyether ladders are probably the most well-known of all marine natural products, not only for their fascinating structures, but also for their characteristic toxicity. A very straightforward model for the biosynthesis of all known polyether ladders, including maitotoxin (the largest and most toxic of this structural family; see formula) is described, but is the structure of this giant molecule really known?