A Metal-Ion-Releasing Probe for DNA Detection by Catalytic Signal Amplification


  • N.G. and M.G. thank Baden-Württemberg for financial support (Landesgraduiertenstipendien). These authors contributed equally to this work.


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Seeing the light: Upon binding to a complementary nucleic acid, a metal-complex–DNA conjugate releases copper(II) ions that activate the precatalyst 1,10-phenanthroline (phen) and amplify the primary signal through catalytic production of a fluorescent dye (DCF). This combination of allosteric signal transduction and catalytic signal amplification imitates biological signaling cascades. tpy=2,2′:6′,2′′-terpyridine.