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Keywords:

  • bioconjugation;
  • protein modifications;
  • transition metals
Thumbnail image of graphical abstract

They make a good couple: Protein modification the transition-metal catalysis enables the selective labeling of proteins and has been demonstrated in complex mixtures. Current examples of such coupling reactions are the Ir-catalyzed reductive amination of lysine residues and the alkylation of tryptophan residues by Rh carbenes in proteins under aqueous conditions (see scheme).