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Transition-Metal Catalysis as a Tool for the Covalent Labeling of Proteins

Authors

  • Jan H. van Maarseveen Dr.,

    1. Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands, Fax: (+31) 20-525-5670
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  • Joost N. H. Reek Prof. Dr.,

    1. Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands, Fax: (+31) 20-525-5670
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  • Jaap Willem Back Dr.

    1. Swammerdam Institute of Life Sciences (Mass Spectrometry group), University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
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Abstract

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They make a good couple: Protein modification the transition-metal catalysis enables the selective labeling of proteins and has been demonstrated in complex mixtures. Current examples of such coupling reactions are the Ir-catalyzed reductive amination of lysine residues and the alkylation of tryptophan residues by Rh carbenes in proteins under aqueous conditions (see scheme).

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