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Sequential One-Pot Reactions Using the Concept of “Site Isolation”



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Acidic and basic sites can be isolated by incorporation in the core of star-shaped polymers (see picture). Fréchet, Hawker, and co-workers have used these polymer-based catalysts for homogeneous-phase one-pot multistep reactions. Similarly, Kaneda et al. have demonstrated the site-isolation concept in heterogeneous systems by use of different types of layered clays.