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A Left-Handed 9-Helix in γ-Peptides: Synthesis and Conformational Studies of Oligomers with Dipeptide Repeats of C-Linked Carbo-γ4-amino Acids and γ-Aminobutyric Acid

Authors

  • Gangavaram V. M. Sharma Dr.,

    1. D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91) 40-2716-0387/2719-3108
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  • Pagadala Jayaprakash,

    1. D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91) 40-2716-0387/2719-3108
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  • Kongari Narsimulu,

    1. Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91)-040-2719-3108
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  • Ampapathi Ravi Sankar Dr.,

    1. Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91)-040-2719-3108
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  • Kondreddy Ravinder Reddy Dr.,

    1. D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91) 40-2716-0387/2719-3108
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  • Palakodety Radha Krishna Dr.,

    1. D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91) 40-2716-0387/2719-3108
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  • Ajit C. Kunwar Dr.

    1. Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: (+91)-040-2719-3108
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  • IICT Communication No. 050802. J.P., K.R.R., and A.R.S. are thankful to CSIR, New Delhi, for financial support. We thank Prof. N. Shamala and P. G. Vasudev for helpful discussions.

Abstract

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A rare twist: A new class of mixed γ-peptides, derived from dipeptide repeats with alternating C-linked carbo-γ4-amino acids and γ-aminobutyric acid have shown the presence of left-handed 9-helices in solution with CDCl3 (see superimposition of 15 minimum-energy structures of a hexapeptide).

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